New publication out!

Although autumn has really arrived with bugs and cold whether, we had a superior week. Janne got his first publication accepted and it is already published. So this will be part of Janne's Ph.D. thesis that will consist of 3 original first author publications that is the requirement in UEF Ph.D. degrees, in addition to the thesis itself, the public defense and 30 ECTS credit points of postgraduate studies. 

Anyway, this paper was published in a prestigious journal called Molecular Pharmaceutics, and with this publication Janne proved that L-type amino acid transporter 1 (LAT1)-utilizing prodrugs of ferulic acid (strong antioxidant among other beneficial effects) can be accumulated into the mouse pancreas due to the high LAT1 expression in pancreatic tissue. This also improved the the ability of ferulic acid to decrease lipid peroxidation and prostaglandin E2 production in the pancreas. Moreover, the prodrugs were hemocompatible and thus, relatively safe to use. Since we have previously shown that these LAT1-utilizing antioxidant prodrugs are also delivered into the brain, they could have beneficial dual effects in the diseases that have overlapping pathological changes, such as Alzheimer's disease and diabetes mellitus. Well, proving that will be the next step for Janne to accomplish... so congratulation, and good luck! 😁

Link to the publication (PubMed).