Another research paper out

We have recently published a very interesting study, part of Ahmed's Ph.D. thesis, in which we administered one of our LAT1-utilizing anti-inflammatory prodrugs to mice and explored their behavior. This was a first study, in which we have proven that increased brain delivery and intrabrain delivery (into the microglia) of anti-inflammatory drug (salicylic acid in this case), alleviated the lipopolysaccharide (LPS)-induced neuroinflammation in mice measured as increased time the mice used in the rotarod and hanging tests. We also identified 399 proteins from the mouse brain by global (un-targeted) proteomic approach that were associated to neuroinflammation. Moreover, we noticed that several of those idenfied proteins were related to critical neuroinflammation pathways and affected by the prodrug treatment. Most importantly, we found that the LAT1-utilizing brain-targeted prodrug of salicylic acid decreased the cellular stress response and transmission across chemical synapses.

This paper was published in the journal called Life Sciences under the title "Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice (link to the publication)"and it is published as open access. Well done Ahmed! Now we are waiting for you to finilize your Ph.D. thesis and to graduate!