Reviewing my postdoc years in Auckland

I have had the pleasure to be involved in writing a review paper with my colleagues at the Auckland Cancer Society Research Centre, New Zealand, during this year. And now that paper is out and it was actually published in very precious journal called Journal of Medicinal Chemistry. Our review of Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity (link to the paper, open access) describes how cytolytic pore-forming perforin can be inhibited by small molecular weight compounds to treat different autoimmune diseases, since perforin, a protein that belong to our immune system, gets a bit carried way in several immunopathologies.

 

The paper nicely summaries what we were able to achieve in this field, of course, I was participating only a while, but it was great to put all the pieces together, memories those great years that we had in Auckland and also to summarize the work that I have continued here at the UEF, in Kuopio. Perforin inhibitors are not in the core of our studies anymore, but the compounds still have potential. Perhaps, some day we will see how they function towards a different target and in different indication. 😀