New Metformin Publication out!

I have totally forgot that we recently published another metformin prodrug paper called "Structural Comparison of Sulfonamide-Based Derivatives That Can Improve Anti-Coagulation Properties of Metformin" in International Journal of Molecular Sciences.

 

In this paper (open access, link here), we have studied with our Polish collaborators the anti-coagulation properties of novel metformin sulfonamide prodrugs that were made in our lab. This was the first study, in which we were able to show that our compounds have significantly elevated glucose utilization in cells, similarly to metformin. Some of the studied compounds also affected beneficially the coagulation parameters, including factor X and antithrombin III activity. We were once again able to understand what kind of structural changes induces what kind of effects and there was, like always, a very thin border between very effective anti-coagulation effects and toxic, cell viability affecting effects.

However, the main finding was, that now we can combine with structural design potential bi-directional activity; anti-hyperglycemic and  anti-coagulant properties to metformin prodrugs or derivatives. Our part (the syntheses) were mainly carried out by our great technician Tiina, so thank you Tiina for your hard work, and also thank you all the co-authors for your great contribution!